Safeguard Scientifics Executives to Moderate Panels at 2007 Mid-Atlantic Capital Conference on October 24th

Safeguard Scientifics, Inc. (NYSE: SFE), a holding company that builds value in growth-stage technology and life sciences companies, today announced that it will host and moderate two business development panels, featuring notable figures from the venture capital, technology and healthcare industries as participants, at the 2007 The Mid-Atlantic Capital (MAC) Conference. Both sessions will be held on Wednesday, October 24, 2007 from 4:30-5:45pm ET in the Philadelphia Marriott Downtown in Philadelphia, PA. PANEL: Corporate Development – Strategic Buyer Insights Moderated by Safeguard’s John A. Loftus, Executive Vice President and Managing Director of the Technology Group, this panel will be held in Salons A & B. Joining Loftus will be renowned corporate development officers from the world’s largest internet and technology companies: Jorge Espinel, Vice President of Corporate Strategy and M&A, AOL LLC Peter Krawiec, Vice President of Worldwide Corporate Development, Amazon.com Jim Mackey, Head of Corporate Finance (M&A), SAP AG (NYSE: SAP) Sam Schwartz, President, Venture Capital and EVP, Internet Strategy, Comcast (NASDAQ: CMCSA) The panel will discuss the most important trends in strategic acquisition from the point of view of the acquirer, and will be followed by a Q&A session. PANEL: Partnering Your Products and Services Moderated by Safeguard’s James A. Datin, Executive Vice President and Managing Director of the Life Sciences Group, this panel will be held in Salons C & D. Joining Datin will be representatives from major life science and financing firms, including: Robert Bagdorf, MD, Executive Director, Worldwide Business Development, Pfizer Inc. (NYSE: PFE) Gary Kurtzman, MD, Vice President, Life Sciences Group, Safeguard Scientifics, Inc. (NYSE: SFE) Joyce Lonergan, Managing Partner and President, SR One Matt Malenfant, Senior Vice President and President North American Lab Business, VWR International, Inc. John McDonough, Senior Vice President, Corporate Development & Operations, Cytyc Development Corporation (NASDAQ:CYTC) Peter Origenes, President, Becton, Dickinson and Company Panelists will discuss M&A strategies in their respective industries: venture capital, hedge funds, private equity, pharmaceuticals, biotechnology, diagnostics, healthcare IT and research. Following the discussion, audience members will be invited to participate in a Q&A session. The 2007 MAC Conference begins on Tuesday, October 23rd. The event is designed to provide informative sessions for conference attendees and showcase up-and-coming companies. The event is held by Mid-Atlantic Capital Alliance, an organization dedicated to promoting corporate growth, investment and entrepreneurship in the Mid-Atlantic region. About Safeguard Safeguard Scientifics, Inc. (NYSE:SFE) builds value in growth-stage technology and life sciences businesses. Safeguard provides growth capital as well as a range of strategic, operational and management resources to our partner companies. Safeguard participates in expansion financings, corporate spin-outs, management buyouts, recapitalizations, industry consolidations and early-stage financings. www.safeguard.com