11.12.2007 12:00:00
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Immunicon Corporation Announces Independent Studies to Be Presented at 2007 San Antonio Breast Cancer Symposium That Confirm Utility of the CellSearch(TM) Circulating Tumor Cell Kit
Immunicon Corporation (NASDAQ-CM:IMMC) announced today that three
independent studies featuring Immunicon’s
CellTracks®
technology and the CellSearch™ Circulating
Tumor Cell Kit will be presented at the 30th
Annual San Antonio Breast Cancer Symposium (SABCS). The meeting is the
premier educational and scientific event in breast oncology and will
take place December 13-16 at the Henry B. Gonzalez Convention Center,
San Antonio, Texas. Research conducted at MD Anderson, the University of
Michigan, and the Lombardi Cancer Center at Georgetown University and
others will be discussed at a Thursday December 13th
afternoon session dedicated solely to circulating tumor cell research in
breast cancer.
Dr. Massimo Cristofanilli, Co-Director of the first Inflammatory Breast
Cancer Clinic at MD Anderson, is senior author on the abstract
describing a large retrospective study involving 312 breast cancer
patients evaluated between 2001 and 2007. The study confirms that CTCs
are a strong independent predictor of survival in metastatic breast
cancer and provides evidence supporting the use of CTCs as a new
stratification method in patients with newly diagnosed Stage IV disease.
The CellSearch™ test is currently FDA-cleared
for monitoring patients with metastatic breast cancer or metastatic
colorectal cancer.
Dr. Minetta Liu will present data indicating that the odds of disease
progression are nearly five times higher for MBC patients with elevated
CTC levels, based on a preliminary analysis of a study from the Lombardi
Cancer Center at Georgetown University Medical Center. The authors
propose that CTC measurement may therefore be particularly helpful in
determining whether treatment is working in MBC patients in whom the
disease cannot be accurately measured by conventional radiological
methods. This group of patients represents approximately 40% of those
currently being treated for MBC.
Results from a University of Michigan study will be presented showing
for the first time that CellTracks® technology
can be used to serially measure CTC in animals, indicating that the
assay may be used in both the animal pre-clinical and human clinical
phases of drug development.
Following the conference, the Immunicon presentations will be posted on
Immunicon’s Web site at http://www.immunicon.com.
The CellSearch™ System includes instruments
and assays that identify, enumerate and characterize CTCs from a blood
test, was developed by Immunicon and is marketed by Veridex, LLC, a
Johnson & Johnson Company, and will be on display at the Veridex booth #
7155 during the meeting. For more about the 2007 San Antonio Breast
Cancer Symposium Annual Meeting, visit http://www.sabcs.org/.
Abstracts will include: Thursday, December 13th 5:00
– 7:00 PM
Abstract No: 111
Circulating tumor cells (CTCs) and prognostic stratification in
metastatic breast cancer (MBC): need for a modification of the AJCC
staging system?
Authors:Dawood S, Broglio K, Reuben J, Handy B, Han
X, Ginsberg C, Remus L, Sun X, Islam R, Kau SW, Fritsche H, Valero
V, Ueno N, Hortobagyi GN, Cristofanilli M. MD Anderson Cancer
Center, Houston, TX
Abstract No: 104 Circulating tumor cells as a reliable assessment of treatment
efficacy in metastatic breast cancer. Authors:Liu MC, Shields P, Isaacs CJD, Warren R,
Cohen P, Wilkinson M, Ottaviano Y, Zhang Y, Shen R, Jasti M,
Gallagher A. Lombardi Cancer Center, Georgetown University Hospital,
Washington, DC; Franklin Square Hospital, Baltimore, MD
Abstract No: 101 Serial detection and characterization of circulating tumor cells
in an animal model. Authors:Eliane JP, Luker KE, Brown M, Repollet M,
Doyle GV, Hayes DF, Luker GD. University of Michigan Medical School;
Immunicon Corporation, Huntingdon Valley, PA About Immunicon Corporation
Immunicon Corporation is developing and commercializing proprietary
cell- and molecular-based human diagnostic and life science research
products, and is providing certain analytical services to pharmaceutical
and biotechnology companies to assist them in developing new therapeutic
agents, with an initial focus on cancer disease management. Immunicon
has developed platform technologies to identify, count and characterize
a small number of rare cells in blood, such as circulating tumor cells
and circulating endothelial cells that are important in many diseases
and biological processes. Immunicon’s
products and underlying technology platforms also have application in
cancer research and may have applications in other fields of medicine,
such as cardiovascular and infectious diseases. For more information,
please visit www.immunicon.com.
Forward-Looking Statements
This press release may contain "forward-looking statements" within the
meaning of the Private Securities Litigation Reform Act of 1995. These
forward-looking statements are often preceded by words such as "hope,” "may,” "believe,” "anticipate,” "plan,” "expect,” "intend,” "assume,” "will”
and similar expressions. Forward-looking statements contained in this
press release include, among others, statements regarding the
anticipated clinical utility of Immunicon’s
products and other statements not of historical fact. Immunicon cautions
investors not to place undue reliance on these forward-looking
statements, which speak only as of the date of this press release, are
based on the current expectations and intent of the management of
Immunicon and involve certain factors, such as risks and uncertainties
that may cause actual results to be far different from those suggested
by these statements. These statements are not guarantees of future
performance and involve risks and uncertainties that are difficult to
predict, including, but not limited to, risks and uncertainties
associated with: Immunicon’s dependence on
Veridex, LLC, a Johnson & Johnson company, in the field of cancer cell
analysis; the ability to earn license and milestone payments under
Immunicon’s agreement with Veridex; Immunicon’s
capital and financing needs; research and development and clinical trial
expenditures; commercialization of product candidates; Immunicon’s
ability to obtain licenses from third parties to commercialize products;
Immunicon’s ability to manage its growth;
obtaining necessary regulatory approvals; reliance on third party
manufacturers and suppliers; reimbursement by third party payors to
Immunicon’s customers; compliance with
applicable manufacturing standards; retaining key personnel; delays in
the development of new products or planned improvements to products;
effectiveness of products compared to competitors’
products; protection of Immunicon’s
intellectual property; conflicts with third party intellectual property;
product liability lawsuits that may be brought against Immunicon; labor,
contract or technical difficulties; and competitive pressures in
Immunicon’s industry. These factors are
discussed in more detail in Immunicon’s
filings with the Securities and Exchange Commission. Except as required
by law, Immunicon accepts no responsibility for updating the information
contained in this press release beyond the published date, whether as a
result of new information, future events or otherwise, or for
modifications made to this document by Internet or wire services.
"Immunicon” and
the Immunicon Corporation logo are registered trademarks of Immunicon
Corporation. ”CellSearch”
is a trademark of Johnson & Johnson. ALL RIGHTS RESERVED.
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