ImmunoGen: Phase 3 Study With Mirvetuximab Soravtansine Fails To Meet Endpoint

(RTTNews) - ImmunoGen, Inc., (IMGN) announced that its Phase 3 FORWARD I trial evaluating the safety and efficacy of mirvetuximab soravtansine compared to chemotherapy in patients with folate receptor alpha (FRa)-positive, platinum-resistant ovarian cancer did not meet its primary endpoint of progression-free survival in either the entire study population or in the pre-specified subset of patients with high FRa expression.

"This study with mirvetuximab did not result in the outcome that we had hoped for in platinum-resistant patients. We will further assess the data from FORWARD I to determine potential next steps with a monotherapy approach. In parallel, we have generated encouraging data with mirvetuximab combination regimens and will evaluate our ongoing studies as an independent path forward to support a registration in ovarian cancer," said Mark Enyedy, ImmunoGen's CEO.