Telix Expands Lutetium-177 Network with Eckert & Ziegler Clinical Supply Agreement

MELBOURNE and LIEGE, Belgium, Feb. 08, 2022 (GLOBE NEWSWIRE) -- Telix Pharmaceuticals Limited (ASX: TLX, Telix, the Company) today announces a global clinical supply agreement with Berlin-based Eckert & Ziegler Strahlen- und Medizintechnik AG (EZAG) for highly pure no-carrier-added (n.c.a.) lutetium-177 (¹⁷⁷Lu), a therapeutic isotope used in Telix’s portfolio of molecularly targeted radiation (MTR) investigational products.

This agreement further enhances Telix’s existing ¹⁷⁷Lu supplier network, which includes a commercial supply agreement with ITM Isotope Technologies Munich SE, and clinical supply agreements with the Australian Nuclear Science and Technology Organisation (ANSTO), and Eczacibasi-Monrol (Monrol).

As Telix advances its late-stage clinical trials using the medical radioisotope ¹⁷⁷Lu, it is building a global supplier network with proximity to major international markets, capable of consistently delivering high-quality, no-carrier-added ¹⁷⁷Lu to patients. Each of the partners in Telix’s carefully selected ¹⁷⁷Lu network deliver unique operating and geographic characteristics, enabling truly global delivery of product for clinical studies and eventually commercial use.

EZAG will immediately commence supply of n.c.a. ¹⁷⁷Lu for use in clinical trials of Telix’s therapeutic candidates TLX591 (¹⁷⁷Lu-rosopatamab for advanced prostate cancer) and TLX250 (¹⁷⁷Lu-girentuximab for kidney cancer).

Dr. Gabriel Liberatore, Telix Group Chief Operating Officer stated, "We are pleased to have established this agreement with EZAG, a premier supplier of high-quality medical radioisotopes, who is now part of our global network of lutetium suppliers. We are committed to working with global partners with a reputation for delivering the highest quality isotopes, and a demonstrated commitment to environmentally sustainable production technologies. Telix’s relationship with EZAG is a multi-isotope partnership and we are delighted to include ¹⁷⁷Lu access as part of the supply chain.”

Dr. Harald Hasselmann, Executive Director responsible for the Medical segment of Eckert & Ziegler continued, "The agreement underlines our outstanding expertise in delivering isotopes to the pharmaceutical industry. With our production facilities in Europe, Asia and in North America, we are excellently positioned to meet the increasing demand for this isotope and related development and manufacturing services. Our recently concluded joint venture with Atom Mines LLC provides us with excellent access to the scarce and indispensable precursor ytterbium-176, enabling us to supply ¹⁷⁷Lu n.c.a. in highest purity and reliably to pharmaceutical customers worldwide.”

About Eckert & Ziegler

Eckert & Ziegler Strahlen- und Medizintechnik AG with approx. 900 employees is one of the world's largest providers of isotope-related components for nuclear medicine and radiation therapy. The company offers services for radiopharmaceuticals at its worldwide locations, from early development to commercialization. Eckert & Ziegler shares (ISIN DE0005659700) are listed in the TecDax index of Deutsche Börse. www.ezag.com

About Telix Pharmaceuticals Limited

Telix is a biopharmaceutical company focused on the development and commercialisation of diagnostic and therapeutic products using Molecularly Targeted Radiation (MTR). Telix is headquartered in Melbourne, Australia with international operations in Belgium, Japan, Switzerland, and the United States. Telix is developing a portfolio of clinical-stage products that address significant unmet medical need in oncology and rare diseases. Telix is listed on the Australian Securities Exchange (ASX: TLX). For more information visit www.telixpharma.com and follow Telix on Twitter (@TelixPharma) and LinkedIn.

Telix’s lead product, gallium-68 (⁶⁸Ga) gozetotide (also known as ⁶⁸Ga PSMA-11) injection for prostate cancer imaging, has been approved by the U.S. Food and Drug Administration (FDA),¹ and by the Australian Therapeutic Goods Administration (TGA).² Telix is also progressing marketing authorisation applications for this investigational candidate in Europe³ and Canada.⁴

Telix Media Contact

Dr. Stewart Holmstrom
Telix Pharmaceuticals Limited
Director Corporate Communications
Email: stewart.holmstrom@telixpharma.com

Eckert & Ziegler Investor Relations

Karolin Riehle
Eckert & Ziegler AG
Email: karolin.riehle@ezag.de

Important Information

This announcement does not constitute an offer to sell, or a solicitation of an offer to buy, securities in the United States, or in any other jurisdiction in which such an offer would be illegal. The securities referred to herein have not been and will not be registered under the United States Securities Act of 1933 (the "U.S. Securities Act”), or under the securities laws of any state or other jurisdiction of the United States and may not be offered or sold within the United States, unless the securities have been registered under the U.S. Securities Act or an exemption from the registration requirements of the U.S. Securities Act is available. This announcement has been authorised for release by Dr. Christian Behrenbruch, Managing Director and Chief Executive Officer. The Telix Pharmaceuticals name and logo are trademarks of Telix Pharmaceuticals Limited and its affiliates (all rights reserved).

¹ ASX disclosure 20 December 2021.
² ASX disclosure 2 November 2021.
³ ASX disclosure 10 December 2021.
⁴ ASX disclosure 16 December 2020.